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$28M Financing Round Will Support Corneal Disease Research

The company’s drug candidate could ‘eliminate the need for surgical intervention.’

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SAN DIEGO — Trefoil Therapeutics announced that it raised $28 million in financing as it develops a treatment for corneal diseases.

The oversubscribed Series A round included new investors Bios Partners, which led the round, and Access Biotechnology. All existing investors, including Hatteras Venture Partners, Aju IB Investment, Correlation Ventures, ExSight Ventures and InFocus Capital Partners, participated in this financing.

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Stella M. Robertson, PhD, co-founder of Bios Partners, and a former vice president in research and development at Alcon Laboratories, will join Trefoil’s Board of Directors.

“Therapeutic options for endothelial corneal diseases are limited aside from cornea transplant surgery, which is invasive, expensive and may require life-long steroid use for immunosuppression,” said Richard L. Abbott, MD, professor emeritus, cornea and external diseases, UCSF Department of Ophthalmology.

“Fuchs dystrophy and other corneal endothelial diseases are among the leading causes of corneal transplantation. There is a high unmet need for a pharmacologic option that would allow treatment of these diseases earlier and potentially reduce or eliminate the need for surgical intervention.”

The company is developing novel engineered fibroblast growth factor-1 proteins (eFGF-1) as a regenerative pharmacologic therapy to treat serious corneal endothelial diseases and epithelial disorders.

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Trefoil’s lead candidate, TTHX1114 ,is an engineered form of the FGF-1 protein designed to reverse vision loss by stimulating endothelial cell proliferation and migration.

Preclinical data has demonstrated TTHX1114’s ability to accelerate corneal clearing in animal models of corneal endothelial dystrophy and enhance healing in corneal chemical injury and herpetic keratopathy.

In human cornea organ culture models, TTHX1114 stimulates the proliferation and migration of endothelial tissue in both normal and diseased corneas, addressing the key defect in corneal endothelial dystrophies.

“Trefoil is developing TTHX1114 with the goal of providing the first regenerative therapeutic agent for the treatment of corneal dystrophy to reverse the vision loss associated with these conditions without the need for surgery for many patients,” said David Eveleth, PhD, co-founder and CEO of Trefoil. “We are grateful to our new and existing investors, who recognize the opportunity we have to make a meaningful difference in the lives of people with sight-destroying corneal diseases and conditions. We look forward to initiating our first clinical study early next year.”

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