Connect with us

Headlines

New Research ‘Shows Promise’ for Age-Related Macular Degeneration

mm

Published

on

It comes from the University at Albany-SUNY.

Research have published promising new findings on age-related macular degeneration, according to the University at Albany-SUNY.

University at Albany doctoral student Janmeet Saini, together with researchers at the Neural Stem Cell Institute at the university’s health sciences campus, published the findings in the journal Cell Stem Cell.

The most common form of AMD, dry AMD, is caused by the degeneration of a layer of cells beneath the retina, called the retinal pigment epithelium (RPE). AMD is the leading cause of blindness in the elderly, the university notes.

The research team derived induced pluripotent stem cell, or iPSCs, from AMD patients and healthy individuals to create a pure population of RPE cells. The iPSC derived RPE from AMD patients showed higher levels of complement and inflammatory factors than those from healthy individuals.

Advertisement

Complement is a vital system of immune surveillance in humans that controls the inflammation and immunity, protecting the healthy host tissues by separating them from diseased cells, foreign invaders and debris.

A delicate balance is maintained between the activation and regulation of complement. However, with aging and in several disorders, including Alzheimer’s disease and AMD, the complement system can become dysregulated, resulting in host tissue damage.

The NSCI research showed that RPE treated with Nicotinamide, a vitamin B3 derivative, showed reduced signs of abnormal AMD proteins in the cultured RPE cells, significant suppression of complement and inflammatory pathways, as well as improved RPE cell survival. Nicotinamide treatment also showed promise for slowing the progression from dry to wet AMD.

Further studies of the way Nicotinamide protects RPE cells should aid in the development of novel AMD therapies, with the goal of preserving vision in the elderly.

The most common form of AMD, dry AMD, is caused by the degeneration of a layer of cells beneath the retina, called the Retinal Pigment Epithelium (RPE)

SPONSORED VIDEO

SPONSORED BY ESSILOR

Introducing CrizalⓇ Rock™

Did you know three out of four people wipe their lenses on their clothes?* Or that one out of three people accidentally drop their glasses at least once a week?* It's no surprise, then, that 93 percent of wearers consider scratch-resistance an important characteristic when choosing lenses.* To prove the durability of new Crizal Rock lenses, we ran tests inspired by real life situations. To learn more about new Crizal Rock, the most scratch-resistant Crizal No-Glare lenses ever made, visit EssilorPRO.com/Crizal-Rock. *Study conducted by ⒸIpsos - Risky behaviors of eyeglass wearers - consumer quantitative research 2019 - declarative results - USA - n= 2345 eyeglass wearers

Promoted Headlines

Advertisement

Advertisement

Subscribe

INVISIONMAG.COM
BULLETINS

Get the most important news and business ideas for eyecare professionals every weekday from INVISION.

Advertisement

Most Popular