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Smoking May Cause Loss of Color Vision, Study Suggests

The findings indicated significant changes in red-green and blue-yellow color vision.

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Smoking more than 20 cigarettes a day can damage your vision, researchers have found.

The study included 71 healthy people who smoked fewer than 15 cigarettes in their lives and 63 who smoked more than 20 cigarettes a day, were diagnosed with tobacco addiction and reported no attempts to stop smoking. The participants were between the ages of 25 and 45 and had normal or corrected-to-normal vision as measured by standard visual acuity charts, according to a Rutgers press release.

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The researchers looked at how participants discriminated contrast levels (subtle differences in shading) and colors while seated 59 inches from a 19-inch cathode-ray tube monitor that displayed stimuli while researchers monitored both eyes simultaneously.

The findings indicated significant changes in the smokers’ red-green and blue-yellow color vision, which suggests that consuming substances with neurotoxic chemicals, such as those in cigarettes, may cause overall color vision loss. They also found that the heavy smokers had a reduced ability to discriminate contrasts and colors when compared to the non-smokers.

“Cigarette smoke consists of numerous compounds that are harmful to health, and it has been linked to a reduction in the thickness of layers in the brain, and to brain lesions, involving areas such as the frontal lobe, which plays a role in voluntary movement and control of thinking, and a decrease in activity in the area of the brain that processes vision,” said co-author Steven Silverstein, director of research at Rutgers University Behavioral Health Care.

“Previous studies have pointed to long-term smoking as doubling the risk for age-related macular degeneration and as a factor causing lens yellowing and inflammation. Our results indicate that excessive use of cigarettes, or chronic exposure to their compounds, affects visual discrimination, supporting the existence of overall deficits in visual processing with tobacco addiction.”

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The research appears in the journal Psychiatry Research.

Although the research did not give a physiological explanation for the results, Silverstein said that since nicotine and smoking harm the vascular system, the study suggests they also damage blood vessels and neurons in the retina.

The Centers for Disease Control and Prevention estimates that 34.3 million adults in the U.S. currently smoke cigarettes and that more than 16 million live with a smoking-related disease, many of which affect the cardiovascular system.

Silverstein said the findings also suggest that research into visual processing impairments in other groups of people, such as those with schizophrenia who often smoke heavily, should take into account their smoking rate or independently examine smokers versus non-smokers.

The study was made available online in November 2018 ahead of final publication in print in January 2019

The study was conducted by researchers from the Perception, Neuroscience and Behavior Laboratory in Brazil with Silverstein as a consultant.

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SPONSORED BY SAFILO

Safilo’s “American Eyes” Video Celebrates Elasta and Emozioni starring ECPs Peter Tacia and Heidi Dancer

For the third year in a row, Safilo has looked to trusted eyecare professionals to star in its American Eyes campaign for its Elasta and Emozioni collections.Their latest testimonials are from Peter Tacia, O.D. and Heidi Dancer, optician, of Alma, MI, talking about two best-selling collections: Elasta and Emozioni.

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$28M Financing Round Will Support Corneal Disease Research

The company’s drug candidate could ‘eliminate the need for surgical intervention.’

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SAN DIEGO — Trefoil Therapeutics announced that it raised $28 million in financing as it develops a treatment for corneal diseases.

The oversubscribed Series A round included new investors Bios Partners, which led the round, and Access Biotechnology. All existing investors, including Hatteras Venture Partners, Aju IB Investment, Correlation Ventures, ExSight Ventures and InFocus Capital Partners, participated in this financing.

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Stella M. Robertson, PhD, co-founder of Bios Partners, and a former vice president in research and development at Alcon Laboratories, will join Trefoil’s Board of Directors.

“Therapeutic options for endothelial corneal diseases are limited aside from cornea transplant surgery, which is invasive, expensive and may require life-long steroid use for immunosuppression,” said Richard L. Abbott, MD, professor emeritus, cornea and external diseases, UCSF Department of Ophthalmology.

“Fuchs dystrophy and other corneal endothelial diseases are among the leading causes of corneal transplantation. There is a high unmet need for a pharmacologic option that would allow treatment of these diseases earlier and potentially reduce or eliminate the need for surgical intervention.”

The company is developing novel engineered fibroblast growth factor-1 proteins (eFGF-1) as a regenerative pharmacologic therapy to treat serious corneal endothelial diseases and epithelial disorders.

Trefoil’s lead candidate, TTHX1114 ,is an engineered form of the FGF-1 protein designed to reverse vision loss by stimulating endothelial cell proliferation and migration.

Preclinical data has demonstrated TTHX1114’s ability to accelerate corneal clearing in animal models of corneal endothelial dystrophy and enhance healing in corneal chemical injury and herpetic keratopathy.

In human cornea organ culture models, TTHX1114 stimulates the proliferation and migration of endothelial tissue in both normal and diseased corneas, addressing the key defect in corneal endothelial dystrophies.

“Trefoil is developing TTHX1114 with the goal of providing the first regenerative therapeutic agent for the treatment of corneal dystrophy to reverse the vision loss associated with these conditions without the need for surgery for many patients,” said David Eveleth, PhD, co-founder and CEO of Trefoil. “We are grateful to our new and existing investors, who recognize the opportunity we have to make a meaningful difference in the lives of people with sight-destroying corneal diseases and conditions. We look forward to initiating our first clinical study early next year.”

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Ransomware Attack Puts 106K Eyecare Patient Records at Risk

The files were ‘rendered inaccessible.’

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Talley Medical Surgical Eyecare Associates in Evansville, IN, was hit by a ransomware attack that may have involved 106,000 patient records, Health IT Security reports.

Talley informed the Department of Health and Human Services of the breach on May 24.

The attack affected the practice’s electronic medical records, email, laptop computer, desktop and networ server, according to Health IT Security.

Files on the devices “were rendered inaccessible,” according to the publication.

The practice has not stated whether it paid to unlock the files.

Data subject to the potential breach included medical information and Social Security numbers.

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The attack began in April.

Spam Fighter quoted Talley’s practice manager saying, “We were able to get our data back, but our practice does not wish to divulge any additional details.”

Read more at Health IT Security

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Contact Lens Maker Acquired

The company sells the Extreme H2O product line.

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ROCHESTER, NY — Clerio Vision Inc., a developer of laser-based vision correction solutions, announced that it has acquired Hydrogel Vision Corp. (HVC).

Financial terms of the deal were not disclosed.

HVC, founded in 2002, is best known for its Extreme H2O product line and its “multiple differentiated offerings that personalize the contact lens wearing experience,” according to a press release. For example, HVC offers lenses in multiple diameters, with smaller lenses to more comfortably fit those with smaller corneas or narrower eyelids, and larger lenses for those with larger corneas or for improved sports performance.

“As Clerio began preparations for its first contact lens offering, we quickly identified HVC as a best-in-class manufacturing partner,” said Alex Zapesochny, co-CEO of Clerio Vision. “We are thrilled to have now fully joined forces with HVC and to further build on its history of offering innovative products of the highest quality.”

HVC contacts are also made from a proprietary ultra-hydrating material that retains up to 99% of its moisture, “which can help to minimize the dryness and itchiness that is often experienced by contact lens wearers late in the day, and may be especially helpful to those who work a lot with screens or live in dryer climates,” according to the release. HVC also distributes the only disposable opaque color contacts for those with astigmatism.

Clerio was founded in 2014 to commercialize breakthrough femtosecond laser research at the University of Rochester. The company’s technology enables the laser writing of unique patterns into contact lenses that optimize visual acuity, including superior correction at both far and near distances for those with presbyopia. Clerio’s multifocal contact lens product is currently in clinical development and is expected to be on the market in the next 18 months.

HVC products are sold in 25 countries, either under the Extreme H2O brand or under one of several private label arrangements. All HVC employees will be retained and its manufacturing and fulfillment activities will continue to be carried out in its locations in Sarasota, FL.

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